Basically substituted 1,4-dihydro-2H-isoquinoline derivatives and process for preparing them

US3980655A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Rudolf Kunstmann · Breckenheim, DE
• Joachim Kaiser · Frankfurt am Main, DE

Key dates

• Filing date: Oct 17, 1974
• Grant date: Sep 14, 1976
• Expiry date: Oct 17, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

1,4-Dihydro-2H-isoquinoline derivatives of the general formula I ##SPC1## in which PA1 R.sup.1 represents hydrogen or straight chain or branched alkyl of 1 to 6 carbon atoms, PA1 R.sup.2 represents low molecular dialkylaminoalkyl, in which both alkyl groups of the dialkylamino group together with the nitrogen atom may also form a 5-, 6- or 7-membered saturated ring in which one carbon atom may be substituted by an oxygen atom, a sulfur atom or another nitrogen atom which may be substituted by hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl, or R.sup.1 and R.sup.2 together may form a 5- or 6-membered saturated ring containing 1 nitrogen atom, PA1 R.sup.3 represents phenyl which may be mono- or di-substituted by halogen, nitro, amino or sulfamoyl, or acylamino or alkyl each containing 1 to 4 carbon atoms, or pyridyl PA1 R.sup.4 and PA1 R.sup.5, which may identical or different, represent hydrogen or alkoxy of 1 to 4 carbon atoms, and PA1 X represent oxygen or sulfur, Their physiologically tolerated salts, process for preparing them. The compounds are active on the coronary circulation and are distinguished in particular by an anti-arrhythmic action and may, therefore, be used in the trea…