Therapeutic piperazinylalkyl-quinazolone-(4)-derivatives
US3984555A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 28, 1971 |
| Grant date | Oct 5, 1976 |
| Priority date | — |
| Expiry date | May 28, 1991 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aryl-substituted piperazinylalkyl-quniazolone-(4) derivatives suitable for se as hypotensive, antihistaminic, and analgesic drugs are described. Process for the preparation of the compounds by (1) intra molecular condensation of the product obtained from the reaction of a halogen carboxylanilide with an aryl piperazine; (2) reaction of an .omega.-halogen-alkyl quinazolone with an aryl piperazine; or (3), reaction of an anthranilic acid with a (4-aryl-piperazinyl-(1) carboxylamide, nitride, amidine, or iminoester, followed by alkylation of the product are also described. Pharmaceutical compositions containing the compounds and halogenalkanoic acid-6-carbamyl anilides useful for preparing the compounds are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.