Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure
US3984556A · kind A · utility
12Cited by
4References
12Claims
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Key dates
| Filing date | May 19, 1975 |
| Grant date | Oct 5, 1976 |
| Priority date | — |
| Expiry date | May 19, 1995 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The compounds are alkyl-substituted-tricyclic quinazolinones of the class of imidazo[2,1-b]quinazolin-5-ones and pyrimido[2,1-b]quinazolin-6-one, e.g., 2-methyl-2,3-dihydro-10-(4'-fluorobenzyl)-imidazo[2,1-b]quinazolin-5(10H)- one, useful, for example, as bronchodilator agents. Processes for preparation of said compounds include the reaction of a N-carboxy anthranilic anhydride (an isatoic anhydride) with an alkyl substituted cyclic pseudothiourea such as a 2-organomercapto-4,5-dihydroimidazole or a 2-organomercapto-3,4,5,6-tetrahydropyrimidine and the cyclization of a 2-(.omega.-hydroxy(branched)alkylamino)-4-quinazolone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.