2-Phenyl-imidazo (4,5-b)pyridines and salts thereof

US3985891A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Eberhard Kutter
• Volkhard Austel · Biberach, DE
• Willi Diederen

Key dates

• Filing date: Aug 22, 1975
• Grant date: Oct 12, 1976
• Expiry date: Aug 22, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the isomeric formulas ##SPC1## Wherein PA1 R.sub.1 is alkoxy of 1 to 4 carbon atoms, allyloxy, benzyloxy, methoxy-ethoxy, methylthio, methylsulfinyl, methylsulfonyl or methylsulfinylethoxy, PA1 R.sub.2 is hydrogen, hydroxyl, methyl, methoxy, ethoxy, fluorine, chlorine, (alkyl of 1 to 4 carbon atoms)-thio, (alkyl of 1 to 4 carbon atoms)-sulfinyl, (alkyl of 1 to 4 carbon atoms)-sulfonyl, dimethylamino or Z-A-O- where PA2 A is alkylene of 2 to 3 carbon atoms, and PA2 Z is chlorine, hydroxyl, methylthio, ethylthio, methylsulfinyl; ethylsulfinyl, methylsulfonyl, ethylsulfonyl, methylamino, dimethylamino, diethylamino, phenethylamino, N-methyl-phenethylamino or N-methyl-dimethoxyphenethylamino, PA1 R.sub.3 is hydrogen or methoxy, Or any two of R.sub.1, R.sub.2 and R.sub.3 together are methylenedioxy, and PA1 R.sub.5 is hydrogen, chlorine or methyl, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as cardiotonics, anticoagulants and for altering the blood pressure.