Process for extracting and purifying 3,6-bis-(5-chloro-2-piperidinyl)-2,5-piperazine dione
US3987046A · kind A · utility
1Cited by
1References
3Claims
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Assignee
Inventors
Key dates
| Filing date | Dec 11, 1975 |
| Grant date | Oct 19, 1976 |
| Priority date | — |
| Expiry date | Dec 11, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to the process for the purification of 3,6-bis(5-chloro-2-piperidinyl)-2,5-piperazinedione dihydrochloride, also known as Compound 593A, obtained as the free base from the fermentation broth of a strain of Streptomyces griseoluteus designated as NRRL 3412 by adsorbtion of the compound on a resin comprising a nonionic macro porous copolymer of styrene cross-linked with divinylbenzene. The resin is eluted with an organic aqueous dilute mineral acid solvent mixture in which the adsorbed compound is soluble. The compound is extracted from the eluate and further purified by fractional crystallization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.