Kit for the rapid preparation of .sup.99m Tc red blood cells

US3988429A · kind A · utility

Assignee

• The United States of America as represented by the United States Energy Research and Development Administration · US

Inventors

• Powell Richards · Bayport, US
• Terry D. Smith · Victoria, US

Key dates

• Filing date: Apr 16, 1975
• Grant date: Oct 26, 1976
• Expiry date: Apr 16, 1995

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method and sample kit for the preparation of .sup.99m Tc-labeled red blood cells in a closed, sterile system. A partially evacuated tube, containing a freeze-dried stannous citrate formulation with heparin as an anticoagulant, allows whole blood to be automatically drawn from the patient. The radioisotope is added at the end of the labeling sequence to minimize operator exposure. Consistent 97% yields in 20 minutes are obtained with small blood samples. Freeze-dried kits have remained stable after five months.