Pharmaceutical compositions containing adenine derivatives

US3989833A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rochus Jonas · Darmstadt, DE
• Werner Mehrhof · Darmstadt, DE
• Karl-Heinz Becker · Darmstadt, DE
• Hans-Jochen Schliep · Traisa, DE

Key dates

• Filing date: Nov 4, 1974
• Grant date: Nov 2, 1976
• Expiry date: Nov 4, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Adenine derivatives of the formula ##SPC1## Wherein R is phenyl or thienyl, and the physiologically acceptable acid addition salts thereof, possess, with good compatibility, cardio-active properties and are produced by the reaction of a purine derivative of the formula ##SPC2## Wherein X is F, Cl, Br, I, SR.sub.1, SOR.sub.1, SO.sub.2 R.sub.1 or OSi(CH.sub.3).sub.3, R.sub.1 being alkyl of 1-4 carbon atoms, phenyl or benzyl, with an amine of the formula ##SPC3## Wherein R has the values given above, or a salt thereof.