Method of treating excessive fibrinolysis with synthetically modified trypsin inhibitors

US3992529A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wolfgang Konig · Hofheim, DE
• Oswald Zwisler
• Gerhard Guthorlein

Key dates

• Filing date: Dec 1, 1975
• Grant date: Nov 16, 1976
• Expiry date: Dec 1, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/1021
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Method of treating excessive fibrinolysis with a modified trypsin-callicrein inhibitor wherein the five carboxyl groups present in the unmodified material are amidated by EQU --(R)(R).sub.X W groups, wherein R is prolyl or ##EQU1## X is an integer from 1 to 10, Y is hydrogen, alkyl, or substituted alkyl and W is --OH, --NH.sub.2, --NHC.sub.2 H.sub.5, --OCH.sub.3, or --OC.sub.2 H.sub.5.