Process for the manufacture of 11.beta.,18-oxido-18,21-dihydroxy-20-oxo-pregnane compounds
US3993644A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 20, 1975 |
| Grant date | Nov 23, 1976 |
| Priority date | — |
| Expiry date | Jan 20, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/0005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new method for converting 11.beta.,18; 18,20-bis-epoxy-pregn-20-enes to 11.beta.,18-epoxy-18,21-dihydroxy-20-oxo-pregnane compounds or functional derivatives thereof is described and claimed. It consists in treating said bis-epoxy compounds with a heavy metal acylate having an acyloxylating action, such as lead - (IV), cerium - (IV), mercury - (II) and thallium - (III) - acylates. Preferred agent is lead tetraacetate. The reaction is conducted in a solvent or suspending agent like benzene or its homologs or chlorinated paraffins, like methylene chloride, preferably at room temperature and optionally in the presence of an acid. In the 21- acylates of 11.beta.,18-epoxy-18,21-dihydroxy-20-oxo-pregnane compounds thus obtained the 21-hydroxy group and any other protected functional groups can be set free in manner known. The process is especially important for the manufacture of aldosterone or its derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.