Biphenylyl derivatives

US3993683A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Josef Nickl
• Erich Muller · Zell am Harmersbach, DE
• Berthold Narr · Biberach, DE
• Walter Haarmann
• Wolfgang Schroter · Zell am Harmersbach, DE
• Rudolf Kadatz · Zell am Harmersbach, DE

Key dates

• Filing date: May 14, 1975
• Grant date: Nov 23, 1976
• Expiry date: May 14, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/185
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##SPC1## Wherein PA1 R.sub.1 is hydrogen, fluorine, bromine, methyl, methoxy, methylthio, nitro, cyano or, when A is other than methylene, R.sub.2 is hydrogen, R.sub.3 is carboxyl, m is 2 and n is 0, also chlorine; PA1 R.sub.2 is hydrogen or fluorine; PA1 R.sub.3 is hydrogen, methyl, hydroxymethyl, carboxyl, (alkoxy of 1 to 6 carbon atoms)-carbonyl, methoxy-(alkoxy of 1 to 6 carbon atoms)-carbonyl, (alkenyloxy of 2 to 6 carbon atoms)-carbonyl, (aralkoxy of 7 to 12 carbon atoms)-carbonyl, phenoxy-carbonyl, pyridylmethoxy-carbonyl, amino-carbonyl, (alkyl of 1 to 3 carbon atoms-amino)-carbonyl, (dialkyl of 1 to 3 carbon atoms-amino)-carbonyl, phenylamino-carbonyl, morpholino-carbonyl, piperidino-carbonyl, thiomorpholino-carbonyl, (1-oxidothiomorpholino)-carbonyl or (1,1-dioxido-thiomorpholino)-carbonyl; PA1 A is methylene, (alkyl of 1 to 3 carbon atoms)-methylene, di-(alkyl of 1 to 3 carbon atoms)-methylene, hydroxymethyl-methylene, hydroxymethylene or carbonyl; PA1 m is 1 or 2; and PA1 n is 0, 1, 2 or 3; PA1 And, when R.sub.3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base. The compounds as well as the salts are useful as antithr…