Process for etherifying .beta.-lactam antibiotics
US3994885A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 30, 1975 |
| Grant date | Nov 30, 1976 |
| Priority date | — |
| Expiry date | Jan 30, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D499/44
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
6-Alkoxylated-6-acylamidopenicillanic acids and 7-alkoxylated-7-acylamidocephalosporin acids and esters thereof, are provided by reacting a 6-acylamidopenicillanic acid ester or a 7-acylamidocephalosporin ester under anhydrous conditions at -90.degree. C. to -15.degree. C. with an alkali metal salt of a lower alkyl alcohol in the presence of an excess of the corresponding alcohol to produce, in situ, the anionic form of the antibiotic which on halogenation with a positive halogen compound, e.g. t-butyl hypochlorite, yields the compound of the invention. Compounds of the invention, e.g. 6-methoxy-6-phenoxyacetamidopenicillanic acid and 7-methoxy-7-[2-(2-thienyl)acetamido]cephalosporanic acid are useful antibiotics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.