N.sup.6 -Substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenines

US3996361A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Walter-Gunar Friebe · Mannheim, DE
• Max Thiel
• Werner Winter · Aachen, DE
• Androniki Roesch · Mannheim, DE
• Wolfgang Schaumann · Heidelberg, DE

Key dates

• Filing date: Dec 10, 1974
• Grant date: Dec 7, 1976
• Expiry date: Dec 10, 1994

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A N.sup.6 -substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenine of the formula ##STR1## wherein R.sub.1 is hydrogen or a lower alkyl radical, and PA1 R.sub.2 is a lower alkyl radical, a lower alkyl radical substituted by at least one of phenyl and hydroxyl, a lower alkenyl radical, a cycloalkyl radical or an aryl radical, or PA1 R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a piperidine, pyrrolidine or morpholine ring, and PA1 R.sub.3 is hydrogen, halogen, a lower alkyl radical or a lower alkoxy radical, Or a salt thereof with a pharmacologically compatible acid, which compounds are characterized by marked anti-edematous activity as well as by activity in reducing capillary permeability.