Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases

US3996382A · kind A · utility

Assignee

• Aktiebolaget Hassle · SE

Inventors

• Peder Bernhard Berntsson
• Arne E. Brandstrom · Gothenburg, SE
• Enar I. Carlsson · Mölndal, SE
• Stig Ake Ingemar Carlsson
• Lars Ek
• Benny Roger Samuelsson
• Sven Erik Sjastrand
• Gert Strandlund · Lindome, SE
• Bengt Arne Hjalmar Ablad · Göteborg, SE

Key dates

• Filing date: Apr 4, 1973
• Grant date: Dec 7, 1976
• Expiry date: Apr 4, 1993

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C271/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R.sup.1 is alkyl or hydroxy alkyl, R.sup.2 is alkoxyalkyl, alkylthioalkyl, alkoxycarbonylaminoalkyl, or alkoxyalkoxy, and R.sup.3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed as are methods for their preparations; Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.