Liquid chromatography-mass spectrometry system and method
US3997298A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 27, 1975 |
| Grant date | Dec 14, 1976 |
| Priority date | — |
| Expiry date | Feb 27, 1995 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/200833
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Liquid chromatography-mass spectrometer apparatus and method are disclosed for analyzing the components of a complex mixture, characterized in that at least a portion of the eluted effluent from the liquid column is continuously introduced directly into the ionization chamber of a chemical ionization mass spectrometer for detection of the eluted sample components. Use is made of restricted capillary tube means for introducing the complex mixture directly into the chemical ionization ion source chamber, and diffusion pump and cryogenic pump means for obtaining the desired vacuum in the ion source chamber. The solvent is used as the agent necessary for chemical ionization, thereby making it unnecessary to remove all of the solvent before introducing the sample into the analyzer. Mass spectra is taken either on a repetitive basis, or the instrument is operable to monitor the total abundance of peaks other than those resulting from the solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.