Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases

US3998790A · kind A · utility

Assignee

• Aktiebolaget Hassle · SE

Inventors

• Arne E. Brandstrom · Gothenburg, SE
• Per A. E. Carlsson · Göteborg, SE
• Stig Ake Ingemar Carlsson
• Hans Rudolf Corrodi
• Lars Ek
• Bengt Arne Hjalmar Ablad · Göteborg, SE

Key dates

• Filing date: Jan 15, 1974
• Grant date: Dec 21, 1976
• Expiry date: Jan 15, 1994

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R' is an isopropyl or tertiarybutyl radical; Z is a member selected from the group consisting of -OR", -SR", and -NHCOOR", R" being a straight or branched lower alkyl radical having 1 to 3 carbon atoms; and n is 1, 2, or 3, are disclosed as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.