Novel, transient pro-drug forms of L-DOPA
US3998799A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 17, 1975 |
| Grant date | Dec 21, 1976 |
| Priority date | — |
| Expiry date | Apr 17, 1995 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/29
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: ##STR1## wherein n represents an integer of from 2 to 50 with respect to formula (V-A), and wherein n represents an integer of from 1 to 50 with respect to formula (V-B); R represents a hydrogen atom, an acyl group, ##STR2## --CO-pyridyl, or --CO--R.sub.3, wherein R.sub.3 is the residue of any N,N-C.sub.1 -C.sub.2 dialkylamino acid or a C.sub.4 -C.sub.6 cycloalkylamino acid; R.sub.1 represents --OH, --O-lower alkyl, --O-benzyl, or a naturally occurring protein amino acid; and R.sub.2 represents ##STR3## --CO-pyridyl, a naturally occurring protein amino acid, 3',4'-L-diacyloxy phenylalanine, or --CO-R.sub.3. These compounds are all useful in the treatment of Parkinson's Disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.