Novel cardiotonic steroids, process for their preparation and therapeutical use
US4000125A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 30, 1975 |
| Grant date | Dec 28, 1976 |
| Priority date | — |
| Expiry date | Jul 30, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J43/003
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel steroid compounds having the formula ##STR1## and their glycoside derivatives containing a pyridazine ring, in which particularly the substituent R.sub.4 is a hydroxy group or a hexopyranoside unit or a chain of two or three hexopyranoside units, as it is normally found in the molecule of the natural glycosides; one or even all the hydroxy groups contained in the R.sub.4 can be either free or etherified or esterified with either a simple carboxylic acid or a carboxylic acid bearing basic groups, or even acetalized with an aldehyde or a ketone, depending on the position and the orientation of a pair of hydroxy groups. The subject compounds are endowed with cardiotonic activity. The invention moreover relates to the process for the preparation of the above compounds and to their therapeutic use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.