Apovincaldehyde

US4001251A · kind A · utility

Assignee

• Synthelabo · FR

Inventors

• Henry Najer · Paris, FR
• Yves Pascal · Paris, FR

Key dates

• Filing date: Jun 5, 1975
• Grant date: Jan 4, 1977
• Expiry date: Jun 5, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D461/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Vincamine and/or its stereoisomers, a known drug, is made from vincaminol and/or its stereoisomers by successive conversion of the latter into apovincaldehyde, apovincamine, and 16-methoxycarbonyl-eburnane, followed by conversion of the last into vincamine either directly by introduction of a 16-hydroxyl group or by hydrolysis, introduction of a 16-hydroxyl group, and re-esterification.