Patent · US Expired

Hydrosoluble extracts of mycobacteria

US4001395A · kind A · utility

8Cited by

0References

15Claims

0Family size

Assignee

Agence Nationale de Valorisation de la Recherche · FR

Inventors

Pierre Jolles · Paris, FR
Daniele Migliore-Samour · Le Kremlin-Bicêtre, FR

Key dates

Filing date	Sep 4, 1975
Grant date	Jan 4, 1977
Priority date	—
Expiry date	Sep 4, 1995

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/55594
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Hydrosoluble extracts of mycobacteria suitable as immunological adjuvants are prepared. These extracts have a molecular weight between 3,500 and 30,000 and adjuvant, non-arthrogenic properties. The delipidated bacterial residues of mycobacteria are subjected to a mild extraction, then the so-obtained substance is isolated and purified by physicochemical methods, or the delipidated bacterial residues of mycobacteria are treated by means of pyridine optionally in the presence of acetic anhydride, then the obtained products are treated with ethanol or water, and the hydrosoluble substances are isolated and purified by physicochemical methods.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.