2-Acyl-4-oxo-pyrazino-isoquinoline derivatives and process for the preparation thereof

US4001411A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Jurgen Seubert · Darmstadt, DE
• Herbert Thomas
• Peter Andrews · Wuppertal, DE

Key dates

• Filing date: Dec 16, 1974
• Grant date: Jan 4, 1977
• Expiry date: Dec 16, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline with an acid or a reactive functional derivative thereof.