2-Hydroxymethyl-thiazole-5-carboxylic acid derivatives
US4001447A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 15, 1975 |
| Grant date | Jan 4, 1977 |
| Priority date | — |
| Expiry date | Oct 15, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/56
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 2-hydroxymethyl-thiazole-5-carboxylic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms, benzoyl, phenyl optionally substituted with at least one halogen and ##STR2## R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, Z is selected from the group of phenyl and phenoxy optionally substituted with at least one halogen and R' is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and alkali metals, alkaline earth metals and aluminum salts, having a marked hypolipemiant activity as well as a clear vasodilatatory activity and which may possess hypocholesterolemiant activity and their preparation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.