Ubiquitous immunopoietic polypeptide (UBIP) and methods

US4002602A · kind A · utility

Inventor

• Gideon Goldstein · Short Hills, US

Key dates

• Filing date: Aug 22, 1975
• Grant date: Jan 11, 1977
• Expiry date: Aug 22, 1995

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/854
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is disclosed a new Ubiquitous Immunopoietic Polypeptide (UBIP) which has been isolated in fluffy white powder form from bovine thymus but which has been found to be present in living cellular tissue of all animals and plants tested including various guinea pig tissues, cells in tissue cultures and tissues from birds, fish, squid, plants, fungi and bacteria, the polypeptide being characterized by its ability to induce in vitro, in nanogram concentrations, the differentiation of both T cell and B cell immunocytes from precursors present in bone marrow or spleen and thus the polypeptide is useful in therapeutic areas involving thymic or immunity deficiencies and the like. The polypeptide also exhibits hypotensive properties. The polypeptide is isolated from living source materials by a combination of sizing techniques and ion-exchange chromatography and may be described by the following amino acid structural sequence: H.sub.2 n-met-gln-ile-phe-val-lys-thr-leu-thr-gly-lys-thr-ile-thr-leu-glu-val-glu- pro-ser-asp-thr-ile-glu-asn-val-lys-ala-lys-ile-gln-asp-lys-glu-gly-ile-pro -pro-asp-gln-gln-arg-leu-ile-phe-ala-gly-lys-gln-leu-glu-asp-gly-arg-thr-le u-ser-asp-tyr-asn-ile-gln-lys-…