1-N-alkyl-aminoglycoside-XK-88 derivatives and methods for their manufacture
US4002608A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 4, 1975 |
| Grant date | Jan 11, 1977 |
| Priority date | — |
| Expiry date | Nov 4, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/234
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1-N-Alkyl-Aminoglycoside-XK-88 derivatives, valuable as antibacterial agents, are prepared by the reaction of an acid addition salt of the corresponding 1-N-unsubstituted-Aminoglycoside-XK-88 antibacterial derivative or of a 2"-N-alkanoyl-Aminoglycoside-XK-88-5 derivative in an inert solvent, preferably a protic solvent containing water, with one equivalent of a hydride-donor reducing agent and with at least one equivalent of an aldehyde. The 2"-N-alkanoyl-Aminoglycoside-XK-88-5 intermediates are prepared by the reaction of a partially neutralized acid addition salt of Aminoglycoside-XK-88-5 with an acylating agent, and isolating the 2"-N-alkanoyl-Aminoglycoside-XK-88-5.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.