Pyrazole derivatives

US4002641A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Eike Moller · Wuppertal, DE
• Karl Meng
• Egbert Wehinger
• Harald Horstmann

Key dates

• Filing date: Dec 13, 1974
• Grant date: Jan 11, 1977
• Expiry date: Dec 13, 1994

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyrazole derivatives of the formula: ##STR1## and pharmaceutically acceptable nontoxic salts thereof WHEREIN PA1 R is hydrogen, trifluoromethyl or alkyl; PA1 R.sup.1 is hydrogen or alkyl; PA1 R.sup.2 is alkyl; PA1 R.sup.3 is aryl substituted by: PA2 A. one or two of the same or different substituents selected from the group consisting of halogen, trifluoromethyl, alkyl, alkenyl and alkoxy; PA2 B. one substituent selected from the group consisting of alkylamino, dialkylamino wherein the alkyl moieties may form a heterocyclic ring with the nitrogen atom to which they are attached, cycloalkyl, cycloalkenyl, trifluoromethoxy, nitro, cyano, carbonamido unsubstituted or substituted by 1 or 2 alkyl moieties, sulphonamido unsubstituted or substituted by 1 or 2 alkyl moieties, and SO.sub.n -alkyl wherein n is 0, 1 or 2; PA2 C. one substituent selected from the group consisting of alkylamino, dialkylamino wherein the alkyl moieties may form a heterocyclic ring with the nitrogen atom to which they are attached, cycloalkyl, cycloalkenyl, trifluoromethoxy, nitro, cyano, carbonamido unsubstituted or substituted by 1 or 2 alkyl moieties, sulphonamido unsubstituted or substituted by 1 or 2 alkyl m…