Method of preparing sterile essentially amorphous cefazolin for reconstitution for parenteral administration
US4002748A · kind A · utility
5Cited by
2References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1976 |
| Grant date | Jan 11, 1977 |
| Priority date | — |
| Expiry date | Jan 19, 1996 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/545
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Sterile, essentially amorphous cefazolin sodium for parenteral administration, having an improved solubility on reconstitution, is prepared by a freeze-drying process wherein a sterile solution of from about 10 to about 25 percent (W/V) of cefazolin sodium is exposed to an environment wherein the temperature is held at from about minus 50.degree. C. to minus 55.degree. C. until the temperature of the solution (frozen) is reduced to minus 48.degree. C. to minus 55.degree. C. before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the water therefrom.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.