Diazepine derivatives in the treatment of tension, agitation and epilepsy
US4002764A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 24, 1975 |
| Grant date | Jan 11, 1977 |
| Priority date | — |
| Expiry date | Nov 24, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D223/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the class of 6-phenyl-4H-s-triazolo [4,3-a][1,4]benzodiazepine-1-carboxamides, their 5-oxides and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties and are active ingredients for therapeutic compositions. In particular, these new compounds have an anti-convulsive and anti-aggressive action and potentiate the action of anaesthetics. Specific embodiments are N,N-dimethyl-6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-c arboxamide, 6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxamide, N,N-dimethyl-6-(o-chlorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodia zepine-1-carboxamide and 6-(o-chlorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carb oxamide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.