.alpha.-Acyl derivatives of digitoxin

US4003998A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Walter Losel
• Herbert Merz · Ingelheim am Rhein, DE
• Wolfgang Hoefke · Wiesbaden, DE
• Werner Traunecker · Münster-Sarmsheim, DE

Key dates

• Filing date: Jul 7, 1975
• Grant date: Jan 18, 1977
• Expiry date: Jul 7, 1995

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/7048
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is ##STR2## R.sub.2 is alkyl of 2 to 15 carbon atoms; mono-substituted alkyl of 1 to 4 carbon atoms, the substituent being halogen, cyano, carbethoxy, optionally substituted phenyl or optionally substituted phenoxy; cycloalkyl of 3 to 6 carbon atoms; cycloalkyl of 3 to 6 carbon atoms-methyl; or N-trifluoromethylcarbonyl-aminoethyl; The compounds are useful as cardiotonics.