Long-acting local subcutaneously-applied anesthetics and compositions containing the same
US4004025A · kind A · utility
Assignees
Inventor
Key dates
| Filing date | Feb 4, 1976 |
| Grant date | Jan 18, 1977 |
| Priority date | — |
| Expiry date | Feb 4, 1996 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/235
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compounds constituting esters of benzoic acids, selected from the group consisting of p-vinyl benzoic acid and p-ethynyl benzoic acid, with an aminoethanol selected from the group consisting of diethylaminoethanol and N-substituted aminoethanols. The esters have the formula ##STR1## where X is selected from the group consisting of ##STR2## or HC.tbd.C and each of R.sub.1 and R.sub.2 is selected from the group consisting of H, lower alkyls containing up to 6 carbon atoms and cycloalkyls. The novel compounds also include inorganic and organic acid salts of said esters. The novel compounds have a unique medicinal function as local subcutaneously-applied anesthetics which have a long-acting effect when administered without vasoconstrictors that heretofore have been used to prevent rapid dissipation of subcutaneously-applied local anesthetics. The invention also embraces compositions containing the compounds and the method of using the novel compounds and compositions as local long-acting subcutaneously-applied anesthetics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.