Preparation of active proteins cross-linked to inactive proteins
US4004979A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 15, 1975 |
| Grant date | Jan 25, 1977 |
| Priority date | — |
| Expiry date | Jan 15, 1995 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/81
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Articles containing active proteins, such as enzymes, crosslinked to an inactive protein are prepared by dispersing and reacting in a solvent an active protein and an inactive protein simultaneously with a crosslinking agent to crosslink the active and inactive proteins together. The degree of crosslinking can be controlled by introducing tris (hydroxymethyl) aminomethane in an amount sufficient to stop chain growth. Optionally, an inert carrier may be present during crosslinking. The resultant crosslinked active and inactive proteins can be in various forms such as solutions, suspensions, gels, films, membranes, granules, pills or tablets.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.