Process for the preparation of thiophenols

US4006186A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Hans D. Engels · Solingen, DE
• Rolf-Jurgen Singer · Wuppertal, DE

Key dates

• Filing date: May 2, 1974
• Grant date: Feb 1, 1977
• Expiry date: May 2, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for the production of thiophenols of the formula ##STR1## in which N IS AN INTEGER FROM 0 TO 5, INCLUSIVE, AND PA1 R is hydroxy, nitro, halogen, alkyl of from 1 to 6 carbon atoms, alkoxy of from 1 to 6 carbon atoms, amino, monoalkylamino or dialkylamino. Which process comprises reacting, in a first step, the corresponding phenylsulfonic acid chloride with hydrazine, hydriodic acid and hydrochloric acid to give the corresponding sulfonehydrazide; and reacting the product so formed, in the second step, to give the corresponding disulfide; and then splitting the resulting material, in the third step, with hydrazine and alkali to form a thiophenolate from which the thiophenol can be liberated by treatment with a mineral acid.