Amino-, mercapto- and -oxy-substituted-phenyl and -phenalkyl imidazoles

US4006243A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Peter Strehlke · Berlin, DE
• Hans-Joachim Kessler
• Ulrich Redmann

Key dates

• Filing date: Apr 11, 1975
• Grant date: Feb 1, 1977
• Expiry date: Apr 11, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein Z is a direct bond or alkylene of 1 - 3 carbon atoms which is unsubstituted or substituted on the carbon atom alpha to the phenyl group by alkyl or unsubstituted or substituted phenyl, R.sub.2 and R.sub.3 singly are H, alkyl, alkoxy, alkylmercapto, halo, nitro or, collectively, C.sub.4 H.sub.4, and R.sub.4 is alkenyl, alkinyl, unsubstituted or substituted phenyl or phenylalkyl, or, when Z is substituted methylene, also alkyl, are useful in combating Germatophyte infections, especially Trichophyton rubrum and mentagrophytes, and yeast infections, especially Candida albicans, as well as bacterial and fungal infections.