Triazolo isoindole derivatives

US4007276A · kind A · utility

Assignee

• Gruppo Lepetit S.p.A. · IT

Inventors

• Amedeo O. Sale · Voghera, IT
• Pietro Consonni · Milano, IT
• Leonard J. Lerner · Milano, IT

Key dates

• Filing date: May 10, 1976
• Grant date: Feb 8, 1977
• Expiry date: May 10, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/46
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New s-triazolo[5,1-a]isoindole derivatives of following formula I ##STR1## wherein R is selected from hydrogen, amino, lower alkyl amino, di-lower alkyl amino, acylamino, diacylamino, benzoylamino, ureido, thioureido, carbethoxythioureido, benzoylthioureido, sulfhydryl, lower alkyl, trifluoromethyl, phenyl, substituted phenyl, pyridyl, methylpyridyl and dimethylpyridyl; and R.sub.1 and R.sub.2 each independently represents hydrogen, chloro or lower alkoxy. A process for their manufacture which comprises the reaction of 2-aminophthalimidine with a reagent R-Z wherein R has the same meaning as above, and Z represents one of the following groups: ##STR2## wherein R.sub.3 is C.sub.1 -C.sub.4 alkyl. The compounds and some of the intermediates of the process are useful as antiinflammatories, analgesics, CNS depressants, antimicrobials and anti-fertility agents.