Process for preparing 3-methyl-3-cephem antibiotics
US4008228A · kind A · utility
3Cited by
1References
6Claims
0Family size
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Inventor
Key dates
| Filing date | Jul 14, 1975 |
| Grant date | Feb 15, 1977 |
| Priority date | — |
| Expiry date | Jul 14, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
7-Acylamino-3-methyl-3-cephem-4-carboxylic acids and esters are prepared via the reductive cleavage of a 3-thio substituted 2-cephem-4-carboxylic acid or ester with hydrogen and Raney nickel or zinc in formic acid and DMF to provide reduction product mixtures of the corresponding 7-substituted 3-methyl-2-cephem-4-acid or ester (I) and 3-exomethylenecepham-4-acid or ester (II). Reduction product mixtures are separable via chromatography and individual I and II are isomerized to 3-methyl-3-cephem antibiotics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.