Halo substituted .beta.-lactam antibiotics
US4008229A · kind A · utility
8Cited by
6References
4Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 11, 1974 |
| Grant date | Feb 15, 1977 |
| Priority date | — |
| Expiry date | Jul 11, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D499/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Imino chlorides of 6-aminopenicillanic esters and 7-aminocephalosporanic esters are reacted at a temperature between -80.degree. and -25.degree. C. with a strong base such as an alkali metal amide of a secondary amine and the generated anion is halogenated to provide the corresponding 6- or 7-halo-N(.alpha.-haloalkylidene) or N(.alpha.-halo-.alpha.-arylmethylidene)-6-aminopenicillanic or 7-aminocephalosporanic esters, respectively. The 6-halopenicillins and 7-halocephalosporins are converted to 6-methoxypenicillins and 7-methoxycephalosporins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.