Pregnane-21-oic acid derivatives

US4008312A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Klaus Annen · Berlin, DE
• Helmut Hofmeister · Berlin, DE
• Henry Laurent
• Klaus Kieslich · Braunschweig, DE
• Hans Wendt · Berlin, DE
• Peter Klaus Mengel

Key dates

• Filing date: Oct 29, 1975
• Grant date: Feb 15, 1977
• Expiry date: Oct 29, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J71/0026
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pregnane-21-oic acid derivatives of the formula ##STR1## wherein THE LINKAGE REPRESENTS A SINGLE BOND OR A DOUBLE BOND; PA1 X is hydrogen, fluorine or chlorine; PA1 Y is methylene, hydroxymethylene, alkanoyloxymethylene, carbonyl, fluoromethylene or chloromethylene; PA1 R.sub.1 is hydrogen, alkyl of 1-6 carbon atoms, phenyl or naphthyl substituted with 0-3 lower alkyl, lower alkoxy or chlorine; and PA1 R.sub.2 represents a hydrogen atom, the cation of a physiologically compatible base or the residue of a physiologically acceptable alcohol of 1-18 carbon atoms. These compounds exhibit useful antiinflammatory activity when topically applied to inflamed skin.