Analogs of LH-RH and process for preparing the same
US4010149A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 7, 1975 |
| Grant date | Mar 1, 1977 |
| Priority date | — |
| Expiry date | Apr 7, 1995 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Peptides having the formula PAC N-Acetyl-N-methylglycyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-Y-L-leucy l-L-arginyl-L-prolyl-Z wherein Y is a D-.alpha.-alkylglycine residue of the formula ##STR1## in which n is an integer of 0 through 3 inclusive and Z is ethylamino group or an ethylamino group which is substituted with 1 to 3 fluorine atoms at the 2-position and pharmaceutically acceptable salts thereof. They show luteinizing hormone-releasing hormone like activities and are prepared by reacting PAC L-histidyl-L-tryptophyl-L-seryl(or L-seryl having a protected hydroxyl group)-L-tyrosyl(or L-tyrosyl having a protected hydroxyl group)-Y-L-leucyl-L-arginyl(or L-arginyl having a protected guanidyl group)-L-prolyl-Z wherein Y and Z are as defined above with PAC a reactive derivative of N-Acetyl-N-methylglycine And, if a protective group is attached, then removing the protective group, and, if necessary, converting further the resultant into an acid addition salt thereof in the usual manner.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.