Acyl derivatives of substituted bis-arylalkylamino compounds

US4010191A · kind A · utility

Assignee

• Deutsche Gold- und Silber-Scheideanstalt Vormals Roessler

Inventors

• Kurt Thiele · Zofingen, CH
• Walter von Bebenburg
• Klaus Posselt

Key dates

• Filing date: Dec 14, 1973
• Grant date: Mar 1, 1977
• Expiry date: Dec 14, 1993

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C233/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein Ar is phenyl or naphthyl, X is oxygen or the group ##STR2## Y is substituted or unsubstituted alkylene of 1-4 carbon atoms, R.sub.1 is acyloxy, acyloxyalkoxy, acylamino or is --N(Alkyl)(Acyl, R.sub.4 is hydrogen or lower alkyl, R.sub.5 is hydrogen, lower alkyl or acyl, and R.sub.2, R.sub.3, R.sub.6 and R.sub.7 are the same or different and are hydrogen, halogen, hydroxy, lower alkoxy, acyloxy, amino, alkylamino, dialkylamino, acylamino, nitro, lower alkyl, lower halogeno alkyl, or lower alkylthio, PA1 Acyl in these radicals being derived from [a] saturated or unsaturated, straight, or branched, substituted or unsubstituted fatty acids of 2-10 carbon atms, [b] substituted or unsubstituted benzoic acids, [c] lower aliphatic mono esters of carbonic acid, or [d] the carbonic acid phenyl mono ester; PA1 And pharmaceutically acceptable salts of these compounds; optically active isomers thereof and diastereomers. The compounds have antiphlogistic, analgesic, antipyretic, broncholytic and coronary circulation regulatory action.