Benzodioxole compounds

US4010267A · kind A · utility

Assignee

• Science Union et Cie, Societe Francaise de Recherche Med. · FR

Inventors

• Gilbert Regnier · Le Plessis-Robinson, FR
• Roger Canevari · Élancourt, FR
• Michel Laubie · Vaucresson, FR
• Jean-Claude Poignant · Les Ulis, FR

Key dates

• Filing date: Mar 26, 1975
• Grant date: Mar 1, 1977
• Expiry date: Mar 26, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/46
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Benzodioxole compounds of the formula: vasodilator ##STR1## WHEREIN R.sub.1 is hydrogen, lower alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl, R.sub.2 is lower-alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl, or R.sub.1 + r.sub.2 are --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 -- or --(CH.sub.2).sub.6 -- and Het is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinazolinyl, 1,3,5 triazinyl or 1,3-thiazolyl, each being optionally substituted by lower-alkyl, lower-alkoxy, hydroxyl or phenyl. These compounds are used as medicines especially as peripheral vasocilator agent and central nervous system stimulant.