Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof

US4011390A · kind A · utility

Assignee

• Schering-Plough Corporation · FR

Inventors

• Marvin J. Weinstein · East Brunswick Township, US
• Peter J. L. Daniels · Cedar Grove, US
• Gerald H. Wagman · East Brunswick Township, US
• Raymond T. Testa · Cedar Grove, US

Key dates

• Filing date: Jun 5, 1974
• Grant date: Mar 8, 1977
• Expiry date: Jun 5, 1994

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/863
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Micromonospora inyoensis strain 1550F-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, mutamicins are produced, said mutamicins being analogs of known aminoglycoside antibiotics differing therefrom with respect to the aminocyclitol subunit.