Process for preparing pyrano[3,4-b]indole or thio pyrano[3,4-b]indole derivatives

US4012417A · kind A · utility

Assignee

• Amerimas Home Products, Inc. · US

Inventors

• Christopher A. Demerson · Plainsboro, US
• Leslie G. Humber · Dollard-Des-Ormeaux, CA
• Thomas A. Dobson · Dollard-Des-Ormeaux, CA
• Ivo L. Jirkovsky · Montréal, CA

Key dates

• Filing date: Mar 5, 1975
• Grant date: Mar 15, 1977
• Expiry date: Mar 5, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives are useful antiinflammatory, analgesic, antibacterial and antifungal agents and methods for their preparation and use are also disclosed.