Glycoside-hydrolase enzyme inhibitors

US4013510A · kind A · utility

Assignee

• Farbenfabriken Bayer Aktiengesellschaft

Inventors

• Werner Frommer
• Walter Puls · Wuppertal, DE
• Dietmar Schafer
• Delf Schmidt · Wuppertal, DE

Key dates

• Filing date: Jul 31, 1974
• Grant date: Mar 22, 1977
• Expiry date: Jul 31, 1994

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/911
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to inhibitors for glycosidehydrolases derived from bacteria of the order Actinomycetales, means for their production comprising cultivation of a microorganism of the order Actinomycetales in appropriate nutrient solutions under conditions most favorable to growth and production of the enzyme inhibitor and recovering, as a new product, glycoside-hydrolase enzyme inhibitors, from the culture as well as the use of said enzyme inhibitors in pharmaceutically acceptable therapeutic compositions in the treatment of conditions indicating obesity, diabetes, pre-diabetes, gastritis, gastric ulcer, hyperlipidemia (arteriosclerosis) and the like. The invention also contemplates the provision of methods of inhibiting the reaction of carbohydrates and glycoside-hydrolase enzymes and particularly carbohydrate-splitting glycoside-hydrolase enzymes of the digestive tract by means of conducting said reaction of said carbohydrates and glycoside-hydrolase enzymes in the presence of a glycoside-hydrolase enzyme inhibitor for said glycoside-hydrolase enzyme derived from a strain of microorganism of the order Actinomycetales. The invention further contemplates the provision of meth…