1-(.omega.-HALOALKYL)-ISATOIC ANHYDRIDES
US4013646A · kind A · utility
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2Claims
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Inventor
Key dates
| Filing date | Aug 6, 1975 |
| Grant date | Mar 22, 1977 |
| Priority date | — |
| Expiry date | Aug 6, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D265/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
CNS depressants of the formulae IA and IB: ##STR1## in which n and p are each 0 or 1, Z.sup.- is an anion and R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3 and R.sub.4 are optional substituents. Compounds IB may be prepared by reducing compounds IA which may be made by reacting a N-(.omega.-haloalkyl) isatoic anhydride with a cyclic pseudothiourea such as a 2-organomercapto-4,5-dihydroimidazole. Compounds IB may be also prepared by cyclizing a 1-(.omega.-haloalkyl)-2,3-dihydro-imidazo[2,1-b]quinazolin-1H-5-one. The compounds are anti-inflammatory, analgesic and immunosuppressant agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.