Preparation of 1,2,4-triazolyl-(1)-phenoxy-acyl-methanes

US4013677A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Claus Stolzer
• Wolfgang Kramer · Wuppertal, DE
• Karl H. Buchel · Burscheid, DE
• Werner Meiser

Key dates

• Filing date: Feb 5, 1975
• Grant date: Mar 22, 1977
• Expiry date: Feb 5, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of a 1,2,4-triazolyl-(1)-phenoxy-acyl-methane of the formula ##STR1## in which R is alkyl or aryl, PA1 Each X independently is alkyl, halogen, alkoxycarbonyl, nitrile, phenyl or nitro, and PA1 n is an integer from 0 to 5, Comprising reacting a dihaloketone of the formula EQU (Hal).sub.2 CH--CO--R in which PA1 Hal is halogen, ##STR2## 1,2,4-TRIAZOLE AND WITH A PHENOL OF THE FORMULA T,0011 IN THE PRESENCE OF AN ACID-BINDING AGENT AND DILUENT, AT A TEMPERATURE OF ABOUT 0.degree. TO 150.degree. C. Advantageously the temperature is about 50.degree. to 90.degree. C and about 1 mole of the phenol, about 1 to 1.2 moles of the 1,2,4-triazole and about 2 to 3 moles of the acid-binding agent are used per mole of the dihaloketone.