Pyrimidin-6-yl acethydroxamic acids, their therapeutic application and their process of preparation
US4013768A · kind A · utility
7Cited by
1References
12Claims
0Family size
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Key dates
| Filing date | Mar 3, 1975 |
| Grant date | Mar 22, 1977 |
| Priority date | — |
| Expiry date | Mar 3, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## in which R is aminocarbonylphenyl in which amino is --NH.sub.2, pyrrolidino, piperidino or morpholino, and Ar is phenyl substituted with chloro, fluoro, trifluoromethyl, methylenedioxy or one or more methoxy. The compounds are prepared by 2-Ar-4-chloro-pyrimidin-6-yl ethylacetate with ##STR2## and then reacting that reaction product with hydroxylamine hydrochloride. The compounds possess vasodilatatory, anti-ulcerous, respiratory analeptic, hypotensive, diuretic, anti-depressive, analgesic, anti-inflammatory and neurotropic properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.