Process for the manufacture of insulin, analogs and derivatives thereof

US4014861A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Rolf Geiger · Frankfurt am Main, DE
• Rainer Obermeier

Key dates

• Filing date: Jun 10, 1975
• Grant date: Mar 29, 1977
• Expiry date: Jun 10, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/46
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for manufacture of insulin, analogs and derivatives thereof by treating an insulin compound wherein the A- and B-chains are linked by a bis-methionyl-carbonyl-bridge, with cyano bromide.