Process for the preparation of cyclopropane derivatives and compounds produced therein

US4014918A · kind A · utility

Assignee

• Roussel Uclaf · FR

Inventor

• Jacques Martel · Bondy, FR

Key dates

• Filing date: Sep 23, 1975
• Grant date: Mar 29, 1977
• Expiry date: Sep 23, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C61/35
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for the preparation of racemic or optically-active cyclopropane carboxylic acid of the formula ##STR1## wherein the CO.sub.2 H substituent on the carbon 1 and the ##STR2## substituent on the carbon 2 are in the cis-position relative to one another, R.sub.1 represents a hydrogen, an alkyl radical, an aralkyl radical, an aryl radical, an alkenyl radical, an alkynyl radical, a cycloalkyl radical, a cycloalkenyl radical, a heterocyclic radical, these radicals being able to be substituted, specifically by lower alkyl or lower alkoxy, or represents a cyano group, an acyl group, a formyl group, an alkoxycarbonyl group or a nitro group, and Z represents the R.sub.2 residue which has the same meaning as R.sub.1 but is identical or different thereto, or the R.sub.3 residue, which represents an allyl radical, a benzyl radical, a cyano group, an acyl group, a formyl group, an alkoxycarbonyl group, or a nitro group, or R.sub.1 and Z together form a saturated or unsaturated carbon homocycle or heterocycle, whose ring can support substituents such as lower alkyls or lower alkoxys, or functions such as ketonic functions, or together form a polycyclic aromatic residue such as a fluorene res…