4-Acylaminophenylacetamidines and a method for their preparation

US4015012A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Hartmund Wollweber · Wuppertal, DE
• Ekkehard Niemers · Wuppertal, DE
• Hans Peter Schulz
• Herbert Thomas
• Peter Andrews · Wuppertal, DE

Key dates

• Filing date: May 21, 1975
• Grant date: Mar 29, 1977
• Expiry date: May 21, 1995

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/155
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New 4-acylaminophenylacetamidines of the formula: ##STR1## in which R is a straight or branched chain alkoxyalkyl having 3 to 8 carbon atoms or straight or branched chain alkenyloxyalkyl having 3 to 8 carbon atoms wherein the alkoxy moiety or alkenyloxy moiety may substituted by alkoxy or phenyl, and including the non-toxic pharmacologically acceptable salts thereof. The products have utility as parasiticides. The products are obtained by either of two methods: (1) via the reaction of an N'-(4-aminophenyl)-N,N-dimethylacetamidine with an acylating agent or (2) via the reaction of a 4-acylaminoaniline with an N,N-dimethylacetamide or N,N-dimethylthioacetamide.