Process for the optical resolution of DL-2-(4-hydroxyphenyl)glycine
US4016205A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 12, 1975 |
| Grant date | Apr 5, 1977 |
| Priority date | — |
| Expiry date | Sep 12, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B57/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a process of resolving D and L-2-(4-hydroxyphenyl) glycine. DL-2-(4-hydroxyphenyl) glycine is treated with d-3-bromo-2-oxo-10-bornanesulfonic acid to form a mixture of d-3-bromo-2-oxo-10-bornanesulfonic acid salts of D- and L-2-(4-Hydroxyphenyl) glycine. This mixture is treated with a solvent selected from the group consisting of isobutyl alcohol, a mixture of a lower alkanol and chloroform, or a mixture of a lower alkanol and toluene. The precipitate containing the d-3-bromo-2-oxo-10 bornanesulfonic acid salt of L-2-(4-hydroxyphenyl) glycine is collected. The corresponding acid salt of D-2-(hydroxyphenyl) glycine is collected from the mother liquor. D- and L-2-(4-hydroxyphenyl) glycine are then recovered by conventional means.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.