Patent · US Expired

Vasoactive intestinal peptide from fowl

US4016258A · kind A · utility

15Cited by

2References

10Claims

0Family size

Inventors

Sami I. Said · Dallas, US
Viktor Mutt · Solna, SE
Ann Nilsson

Key dates

Filing date	Aug 5, 1975
Grant date	Apr 5, 1977
Priority date	—
Expiry date	Aug 5, 1995

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S930/17
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A polypeptide having important biological activity including systemic vasodilation, hypotension, increased cardiac output and bronchodilation is isolated from intestines of chickens. The isolation procedure for purification includes extraction, ion-exchange chromatography, gel chromatography and countercurrent distribution separation. The polypeptide has the general amino acid structure: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Ser-Arg-Phe-Arg-Lys-Gln-Met-Ala-Val -Lys-Lys-Tyr-Leu-Asn-Ser-Val-Leu-Thr-NH.sub.2. Therapeutic biological actions may be produced in animals and humans by administration of 0.02-10 .mu.g of the peptide per kg of body weight.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.