Process for the preparation of cephalosporins from the corresponding azetidinone-thiazoline derivatives
US4018776A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 4, 1975 |
| Grant date | Apr 19, 1977 |
| Priority date | — |
| Expiry date | Aug 4, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is disclosed for preparing a cephalosporin of structure: ##STR1## where R is selected from the class consisting of hydrogen, alkyl having from 1 to 4 carbon atoms, cyano-methyl, thienyl-methyl, furyl-methyl, naphthyl-methyl, phenyl-methyl, phenoxy-methyl, phenyl-isopropyl, phenoxy-isopropyl, pyridyl-4-thiomethyl, tetrazolyl-1-methyl; R.sup.1 is selected from the class consisting of hydroxy, alkoxy having from 1 to 4 carbon atoms, trichloroethoxy, benzyloxy, p-methoxy-benzyloxy, p-nitrobenzyloxy, benzhydryloxy, triphenylmethoxy, phenacyloxy, p-halophenacyloxy; and Z is selected from the class consisting of hydrogen, hydroxy, --O--Alkyl, --O--CO--Alkyl, --Br, --I, --NH.sub.2, --O--COCH.sub.3, --O--CO--NH.sub.2, and an --S-mononuclear nitrogen heterocyclic ring, PA1 Wherein a compound of structure: ##STR2## where R, R.sup.1 and Z have the above meanings, is reacted with iodine in a suitable aqueous solvent at a temperature between 5.degree. and 80.degree. C in the presence of an oxide of a heavy metal or with a free radical initiator under the influence of light or heat, to give a compound of structure: ##STR3## in which R, R.sup.1 and Z have the above meanings, AND THE SAID…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.